Phytoncides are currently the subject of intense Phyto Medicine research by many institutes including the Sloan Kettering Cancer Center. They are the focus of very active and ongoing early-phase medical research into oncology and chemoprevention.
Phytoncides are not yet an approved cancer cure, but research has shown compelling chemopreventative and antiproliferative results in laboratory models and early human trials.
Preclinical mechanisms are showing induced apoptosis in cancer cells suppressing the P13K/AKY pathway & down regulating RAS signaling proteins responsible for tumor proliferation. (Sloan Kettering)
In clinical human trials in phase 1/11 settings, high dose oral d-Limonene (1 to 12g per day) exhibited partial responses or disease stabilization in patients with some cancers. d-Limonene has been seen to reduce pro-inflammatory cytokines such as TNF & 1lL-6. Metabolic regulation helps lower oxidative stress and antimicrobial activity has been demonstrated against common pathogens like C. Albicans, E. Coli and S.Aureus. d-Linonene has been demonstrated to have a high lipophilicity , systemic bioavailability and low general toxicity.
d-Limonene and r-Limonene (found in the peel of citrus fruits) are mono-terpenes that are believed to be involved in Apoptosis - this signals the pathways to stop cancer cells multiplying.
Limonenes are potential anti-cancer compounds that exert a chemopreventative activity. Stimulating the detoxification of carcinogenic compounds and limiting tumor growth and angiogenesis. They increase Box expression, release cytochrome C and activate the caspase pathway.
They are believed to be involved in the inhibition of tumor initiation, growth and angiogenesis, increase the expression of p53, decrease the activity of Ras/Raf/MEK/ERK P13K/AKT pathways, decrease the expression of VEGP and
increase the activities of Man-6-P/IGF2R and TGF-B11R receptors
Positive effects on NK (Natural Killer) activities were demonstrated not only in the in vitro treatment of tumor cell lines with monoterpenes released from trees, such as d-limonene and α-pinene, but also in forest bathing trips by increasing intracellular levels of anti-tumor proteins such as perforin, granulysin, and granzymes A/B (60).
Anti-tumor effects of pinenes are well established on tumor lymphocytes as well as tumor cell lines . Matsuo et al. identified proapoptotic and anti-metastatic activities of α-pinene in a melanoma model. Later, it was revealed in human hepatoma Bel-7402 cells that the proapoptotic effect of α-pinene is associated with induction of G2/M cell cycle arrest. In addition, α-pinene triggers oxidative stress signaling pathways in A549 and HepG2 cells
STANDARDIZED BOTANICAL TERPENE THERAPY
Our delivery systems trigger rapid olfactory-vagal and dermal stimulation, offering a non-invasive, evidence backed protocol for corticol reduction, nervous system down-regulation, autonomic nervous system (ANS) reset and beyond.
All of our botanicals have known anti-inflammatory, anti-bacterial, anti-oxidative, anti-stress and anti-cancer properties.
All of the terpenes used are grown, harvested and distilled in-house providing total quality control at all levels.
OUR MISSION is to quantify and standardize airborne plant chemistry
CORE SCIENTIFIC PILLARS:
1. With our actives grown, harvested and distilled in-house we are in charge of quality control at all levels.
2. Our products are aimed solely at targeted neuro-receptors, they are formulated specifically to bind with GABA-A receptors for rapid autonomic system response.
3. Bio-Photonic Preservation of our liquid products which are packaged with care into dark blue/violet glass packaging to prevent UV-induced oxidation and maintain therapeutic potency and efficacy.
4. Our Pharmacopeia Label System is strictly structured after clinical monograph standards featuring ingredient information, terpene concentrations, lot tracking, storage requirements and usage instructions.
d-Limonene is one of our most important terpenes. It is lipophilic (fat soluble) making for easy absorption as it passes through biologic membranes.
We utilize the benefits of the following applications:
INHALATION - Volatile Organic Compounds (VOC’s) which vaporize easily at room temperature.
Inhaled vapor enters the lungs and diffuses directly across the alveolar membrane into the bloodstream. Thereby by-passing the first pass liver metabolism allowing small amounts of d-Limonene and other terpenes to enter the systemic circulation directly.
DERMAL ABSORPTION - d-Limonene and other terpenes penetrate skins lipid layers relatively well, providing clinicians and self-care customers with precise, non-invasive therapeutic tools for neuro-endocrine and other regulation. Please visit www.redskywellnessbotanicals.com for more information.
